The Chiefs were aided by the turnover-prone visitors, who threw three interceptions and lost three fumbles.
Santa Fe scored six touchdowns in the opening period, starting with freshman Ben Reeders' 3-yard run two minutes into the contest. Senior Matt Bodenhamer fired a 12-yard TD pass to junior Alex Martinez and returned a punt 33 yards for a touchdown a minute later.
Reeders went in from 14 yards out, Martinez found the goal line at the end of a 5-yard run and senior Lucas Miller broke off a 53-yard dash with 11 seconds left in the frame.
Freshman Ben Hinz saw considerable action at quarterback for the Chiefs, an scored on runs of 10 yards and 18 yards to extend the margin to 51-0 midway through the third quarter. Hinz also threw a 25-yard touchdown pass to junior Keaton Graf during the final frame.
The Greyhounds rang up three touchdowns during the game's final 15 minutes. Freshman Mario Persell caught throws of 5 and 39 yards from junior Jeffery Hall and sophomore Trevor Harrison recovered a fumble in the end zone.
Sweet Springs (2-4, 1-3 I-70) returns home Friday to face Crest Ridge, while Santa Fe (3-3, 2-3) heads to winless Orrick.
Salisbury 35, Slater 0
SLATER -- Senior Austin Wyatt ran for 97 yards and two touchdowns and threw for 186 yards and a score Friday to lead second-ranked Salisbury to a 35-0 Lewis and Clark Conference win at Slater.
The Panthers held the Purple to 37 yards in total offense while posting their fourth shutout of the season, although this was by the narrowest margin of them.
Salisbury didn't score its first touchdown until sophomore Daniel Linneman plunged in from two yards out with 2:25 left in the opening period. However, the Panthers had two big plays during the second quarter, Wyatt connecting with Linneman on a 60-yard pass and then breaking off a 40-yard run to head into the break with a 21-0 lead.
Wyatt added a 7-yard touchdown run in the third period and senior Jake Latamondeer went on a 61-yard dash during the final frame.
Latamondeer had 113 rushing yards for the Panthers (6-0, 2-0 L&C), which plays Friday at eight-ranked Westran -- suffering its first loss of the season last week, 16-13, to former Marshall coach Paul Thomas' Marceline club.
Senior Drew Weiker accounted for most of the Wildcats' offense with 28 all-purpose yards, while junior Mat Curren provided a highlight with a 34-yard interception return.
Slater (1-5, 0-2) will head to Paris in search of a league victory Friday.