Junior Shadow Wiskur banged out three hits and drove in a pair of runs, the second with a fourth-inning triple to give the Lady Mustangs (2-0) a 5-1 lead. She also led off the sixth with a single and scored on an error.
The Lady Chiefs (2-1) didn't get a hit until junior Erica Lane singled with one out in the seventh. Lane walked and scored Santa Fe's second run on senior Becca Woodson's grounder in the fifth.
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